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Reaction of 2-Trifluoroacetyl-1,8-Bis(dimethylamino)naphthalene with Strong Organic Bases: Acidic Ionization of 1-NMe2 Group Resulting in the Formation of Benzo[g]indole Derivatives versus Nucleophilic Addition to C=O Group featured image

Reaction of 2-Trifluoroacetyl-1,8-Bis(dimethylamino)naphthalene with Strong Organic Bases: Acidic Ionization of 1-NMe2 Group Resulting in the Formation of Benzo[g]indole Derivatives versus Nucleophilic Addition to C=O Group

A novel approach to pyrrole ring closure in 2-trifluoroacetyl- and 2-ethoxycarbonyl-1,8-bis(dimethylamino)naphthalenes via treatment with …

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Dr. Alexander Antonov
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Base-promoted transformation of 2-C(O)R-1,8-bis(dimethylamino)naphthalenes into benzo[g]indole derivatives featured image

Base-promoted transformation of 2-C(O)R-1,8-bis(dimethylamino)naphthalenes into benzo[g]indole derivatives

1,8-Bis(dimethylamino)naphthalenes bearing 2-positioned trifluoroacetyl or ethoxycarbonyl group on treatment with 2-lithio-1,8-bis-dimethylamino)naphthalene undergo base-promoted …

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