![Reaction of 2-Trifluoroacetyl-1,8-Bis(dimethylamino)naphthalene with Strong Organic Bases: Acidic Ionization of 1-NMe2 Group Resulting in the Formation of Benzo[g]indole Derivatives versus Nucleophilic Addition to C=O Group featured image](/publications/08/publications/08/featured_hu_91ae6f6dd030bd67.webp)
A novel approach to pyrrole ring closure in 2-trifluoroacetyl- and 2-ethoxycarbonyl-1,8-bis(dimethylamino)naphthalenes via treatment with …
![10-Dimethylamino derivatives of benzo[h]quinoline and benzo[h]quinazolines: fluorescent proton sponge analogues with opposed peri-NMe2/–N= groups. How to distinguish between proton sponges and pseudo-proton sponges featured image](/publications/07/publications/07/featured_hu_520cda48527b48d8.webp)
For the first time, 10-dimethylamino derivatives of benzo[h]quinoline 6 and benzo[h]quinazoline 7a–e as mixed analogues of archetypal 1,8-bis(dimethylamino)naphthalene (“proton …
![Tandem synthesis of 10- dimethylaminobenzo[h]quinazolines from 2-ketimino-1,8-bis(dimethylamino)naphthalenes via nucleophilic replacement of the unactivated aromatic NMe2 group featured image](/publications/06/publications/06/featured_hu_effab4874e9d2526.webp)
For the first time, 10-dimethylamino derivatives of benzo[h]quinoline 6 and benzo[h]quinazoline 7a–e as mixed analogues of archetypal 1,8-bis(dimethylamino)naphthalene (“proton …
It has been found that 1,8-bis(dimethylamino)naphthalene (DMAN), unlike N,N-dimethylaniline, undergoes ring metallation in the n-BuLi–TMEDA–Et2O system with a low selectivity and …
![Base-promoted transformation of 2-C(O)R-1,8-bis(dimethylamino)naphthalenes into benzo[g]indole derivatives featured image](/publications/04/publications/04/featured_hu_21d067fcb054fe1c.webp)
1,8-Bis(dimethylamino)naphthalenes bearing 2-positioned trifluoroacetyl or ethoxycarbonyl group on treatment with 2-lithio-1,8-bis-dimethylamino)naphthalene undergo base-promoted …
A series of 2-ketimines and 2,7-diketimines of 1,8-bis(dimethylamino)naphthalene (proton sponge, DMAN) have been obtained and converted into the corresponding ketones via acidic …
A possibility of non-conventional two-step protonation of 1,8-bis(dimethylamino)naphthalene (proton sponge) is discussed. Unlike the generally accepted mechanism, involving …
It has been shown that azomethines, hydrazones, and oximes derived from 2(7)-carbonyl derivatives of 1,8-bis(dimethylamino)naphthalene can undergo acid-catalyzed heterocyclization …
