Experimental and theoretical results are presented based on vibrational spectra and motional dynamics of 1,8-bis(dimethylamino)naphthalene (DMAN) and its protonated forms (DMANH+ …
The protonation of the carboxamide nitrogen atom is an essential part of in vivo and in vitro processes (cis-trans isomerization, amides hydrolysis etc). This phenomenon is well …
The structure and protonation behaviour of four ortho-arylketimines of 1,8-bis(dimethylamonio)naphthalene with a different number of methoxy groups in an aromatic substituent were …
![Reaction of 2-Trifluoroacetyl-1,8-Bis(dimethylamino)naphthalene with Strong Organic Bases: Acidic Ionization of 1-NMe2 Group Resulting in the Formation of Benzo[g]indole Derivatives versus Nucleophilic Addition to C=O Group featured image](/publications/08/publications/08/featured_hu_91ae6f6dd030bd67.webp)
A novel approach to pyrrole ring closure in 2-trifluoroacetyl- and 2-ethoxycarbonyl-1,8-bis(dimethylamino)naphthalenes via treatment with …
It has been found that 1,8-bis(dimethylamino)naphthalene (DMAN), unlike N,N-dimethylaniline, undergoes ring metallation in the n-BuLi–TMEDA–Et2O system with a low selectivity and …
![Base-promoted transformation of 2-C(O)R-1,8-bis(dimethylamino)naphthalenes into benzo[g]indole derivatives featured image](/publications/04/publications/04/featured_hu_21d067fcb054fe1c.webp)
1,8-Bis(dimethylamino)naphthalenes bearing 2-positioned trifluoroacetyl or ethoxycarbonyl group on treatment with 2-lithio-1,8-bis-dimethylamino)naphthalene undergo base-promoted …
A possibility of non-conventional two-step protonation of 1,8-bis(dimethylamino)naphthalene (proton sponge) is discussed. Unlike the generally accepted mechanism, involving …